Table 1.
Summary of Laboratory Investigations in Two Siblings at the Time of Diagnosis
| Laboratory parameters | Patient 1 (age: 16 months) | Patient 2 (age: 12 months) | Reference value |
|---|---|---|---|
| WBC (cells/mm3) | 5700 | 3900 | 6000–17000 |
| Lymphocyte (cells/mm3) | 1938 | 663 | 3000–9500 |
| Neutrophil (cells/mm3) | 1026 | 2496 | 1500–8500 |
| Eosinophil (cells/mm3) | 114 | 195 | 165–465 |
| IgG (mg/dL) | 849 | 875† | 246–904 |
| IgM (mg/dL) | 256 | 44 | 40–143 |
| IgA (mg/dL) | 47 | 174 | 27–66 |
| IgE (IU/mL) | 475 | 170 | Up to 68 |
| Anti-D IgG (IU/mL) | < 0.01 | 0.006 |
< 0.1: No response 0.1–1: Poor response ˃1: Normal response |
| Anti-T IgG (IU/mL) | 0.05 | 0.39 |
< 0.1: No response 0.1–1: Poor response ˃1: Normal response |
| Plt (× 103 cells/mm3) | 1091 | 738 | 150–450 |
| CD3 + T cells (% of lymphocytes) | 79% | 30% | 50–90 |
| CD4 + T cells (% of lymphocytes) | 12% | 22% | 20–65 |
| CD8 + T cells (% of lymphocytes) | 50% | 2% | 5–40 |
| CD19 + B cells (% of lymphocytes) | 2% | 27.5% | 3–40 |
| CD16 + NK cells (% of lymphocytes) | 15% | 16.7% | 3–15 |
| CD56 + NK cells (% of lymphocytes) | 19% | 21% | 3–15 |
| NBT | 100% | 100% | > 95 |
| CRP | 112 | 3 | < 10 |
| LTT | |||
| PHA | 4.8 | 4.9 | ≥ 3 |
| BCG | 1.1 | 1.4 | ≥ 2.5 |
| Candida | 1.8 | 2.0 | ≥ 2.5 |
Bold items indicate abnormal parameters according to the reference ranges for ages
WBC white blood cell, Ig immunoglobulin, Anti-D anti-diphtheria, Anti-T anti-tetanus, Plt platelet, NK natural killer, CRP C-reactive protein, LTT lymphocyte transformation test, PHA phytohemagglutinin, BCG Bacillus Calmette-Guérin
†While on exogenous immunoglobulin