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. 2022 Dec 23;21:289. doi: 10.1186/s12933-022-01729-9

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — Decomposition of the total association of general and central obesity and the risk of CVD into direct and indirect associations mediated by the TyG index. BMI body mass index, CI confidence interval, CVD cardiovascular disease, HR hazard ratio, TyG triglyceride-glucose index, WC waist circumference, WHR waist circumference to hip ratio, WHTR waist circumference to height ratio. Compared with normal weight participants for general obesity and WC < 90 cm in men or < 85 cm in women, WHR < 0.90 in men or < 0.80 in women, and WHTR < 0.60 as a reference for central obesity. All models were adjusted for age, sex, education, income, smoking status, drinking status, history of hypertension, diabetes, dyslipidemia, antihypertensive agents, antidiabetic agents, lipide-lowering agents, systolic blood pressure, diastolic blood pressure, total cholesterol, high density lipoprotein cholesterol, and high sensitivity C-reactive protein