Table 2.
Change from baseline in objective measures of affected ankle tenderness, joint function, and swelling
| Least squares mean (SE) | DDEA 2.32% gel BID (N = 122) | DDEA 1.16% gel QID (N = 128) | Least squares mean difference (95% CI)a |
|---|---|---|---|
| Algometry, N/cm2 | |||
| Day 3 | 6.92 (0.85) | 5.73 (0.83) | 1.20 (−1.13, 3.54) |
| Day 5 | 9.84 (0.97) | 10.76 (0.94) | −0.93 (−3.60, 1.74) |
| Day 8 | 17.06 (1.19) | 15.60 (1.16) | 1.46 (−1.83, 4.74) |
| Karlsson Scoring | |||
| Day 3 | 16.26 (1.07) | 15.52 (1.05) | 0.74 (−2.23, 3.71) |
| Day 5 | 27.94 (1.46) | 28.22 (1.43) | −0.28 (−4.33, 3.77) |
| Day 8 | 41.87 (1.59) | 39.75 (1.56) | 2.12 (−2.29, 6.54) |
| Figure of Eight Method | |||
| Day 3 | −0.42 (0.09) | −0.24 (0.09) | −0.18 (− 0.44, 0.07) |
| Day 5 | −0.97 (0.10) | −0.57 (0.10) | −0.39 (− 0.66, − 0.12) |
| Day 8 | −1.25 (0.10) | −0.87 (0.10) | −0.38 (− 0.66, − 0.10) |
BID twice daily, CI confidence interval, DDEA diclofenac diethylamine, QID four times daily, SE standard error
aConfidence intervals encompass zero, indicating no significant difference between groups