Figure 3.

Systematic study of protein folding affected by the inhibition of protein N-glycosylation using Tm. (A) Comparison of the cysteine exposure rates between the Tm-treated and control samples. (B) Number of proteins within different ranges of the exposure rate changes. (C) GO enrichment analysis among proteins with cysteine in highly unfolded or stable regions. Fold enrichment values were calculated by comparing the frequency of total proteins annotated to that term in all identified proteins to the frequency representing the number of proteins in the highly damaged or stable group that fall under the same term.