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. 2022 Dec 24;13(12):1070. doi: 10.1038/s41419-022-05515-z

Fig. 7. AEC2 3D model confirms UHRF1-regulated ferroptosis in PF.

Fig. 7

A Representative HE staining of primary AEC2 cell 3D culture treated by SiO2 with or without UHRF1 siRNA for 14 days. B quantification of C11-BODIPY fluorescence in primary AEC2 organoid cells (**P < 0.01 versus control group, #P < 0.01 versus SiO2-treated group). C MDA concentration in cell lysates from primary AEC2 organoid (**P < 0.01 versus control group, #P < 0.01 versus SiO2-treated group). D GSH/GSSG ratio of primary AEC2 organoid cells (**P < 0.01 versus control group, #P < 0.01 versus SiO2-treated group). E Intracellular Fe2+ fluorescence intensity was quantified in both primary AEC2 organoid cells (**P < 0.01 versus control group, #P < 0.01 versus SiO2-treated group; right panel). F Representative HE and UHRF1 IHC staining in normal and silicosis patient lung tissues (scale bars, 100 µm).