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. 2022 Dec 12;24(12):732–740. doi: 10.22074/CELLJ.2022.557327.1043

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Fig 6 — NOX2/p38 mediates the effect of CTRP1 on macrophages. A, B. Protein expression of NOX2, p-p38, and total p38 in activated or CTRP1-treated macrophages (n=6). C. Macrophages were activated by IFN-γ+LPS and treated with recombinant CTRP1 (8 μg/mL) and/or SB203580 (10 Μm). The release of pro-inflammatory cytokines in macrophages was detected using ELISA (n=6). D, E. Fibroblasts were co-cultured with activated CTRP1- and/ or SB203580-treated macrophages. D. Fibroblast proliferation detected by using the CCK-8 assay (n=6). E. Transcription of fibrosis markers in fibroblasts (n=6). TNF-α; Tumor necrosis factor-α, CON; Control, IFN-γ; Interferonγ, LPS; Lipopolysaccharide, *; P<0.05 vs. CON group, and ^#; P<0.05 vs. IFN-γ+LPS group.