FIGURE 4:

T cells from the kidneys of Dahl SS/Animal exhibit significantly more differentially methylated regions (DMRs) in T cells isolated from the SS/Animal compared to SS/Grain (A). The DMRs in the T cells isolated from the kidney were primarily hypermethylated (B). Comparison of genes up- and downregulated in T cells isolated from the kidney of SS/Animal and SS/Grain rats fed the high salt (4.0% NaCl) diet (C-F) showed upregulation of inflammatory, T-cell signaling pathways in SS/Animal (C-D). Comparison of genes up- and down-regulated in T cells isolated from the kidney of SS/Grain fed the low salt (LS, 0.4% NaCl) or the HS diet demonstrated downregulation of pathways related primarily to metabolic processes during HS (E-F). TSS=transcription start site, n=4 pools/group, 3 rats/pool, *P<.05 vs SS/Grain. Reproduced from Abais-Battad et al ³³ and Dasinger et al ⁵⁰.