Table 3.
Factors associated with ≥ 5% weight loss within the first year of IPF
| OR | CI | p value | |
|---|---|---|---|
| Univariate analysis | |||
| ≥ 200 mL loss of FVC | 3.03 | [0.985, 9.341] | 0.053 |
| Antifibrotic use | 1.907 | [0.673, 5.405] | 0.22 |
| ARB use | 3.071 | [0.917, 10.28] | 0.07 |
| ACE use | 0.307 | [0.035, 2.67] | 0.28 |
| Pulmonary Rehab | 1.467 | [0.413, 4.902] | 0.57 |
| Smoking | 1.071 | [0.386, 5.577] | 0.90 |
| GERD | 1.65 | [0.565, 4.433] | 0.34 |
| PPI | 0.80 | [0.286, 2.21] | 0.66 |
| COPD | 0.228 | [0.027, 1.924] | 0.17 |
| Diabetes | 1.641 | [0.467, 5.767] | 0.30 |
| Pulmonary hypertension | 1.211 | [0.552, 6.99] | 0.83 |
| Sleep apnea | 0.647 | [0.123, 3.407] | 0.61 |
| Atrial fibrillation | 0.480 | [0.094, 2.437] | 0.38 |
| Oxygen use | 5.333 | [1.762, 16.15] | 0.003* |
| Gender | 1.286 | [0.429, 3.852] | 0.65 |
| Multivariable analysis | |||
| Oxygen use | 13.167 | [3.059–56.68] | 0.0005* |
| ≥ 200 mL loss of FVC | 5.44 | [1.28, 22.98] | .021* |
| Age | 1.034 | [0.96, 1.114] | 0.38 |
ARB: angiotensin receptor blocker; ACE: Angiotensin converting enzyme inhibitor; BMI: body mass index; COPD: chronic obstructive lung disease; DLCO: diffusion limitation for carbon monoxide; FVC: forced vital capacity; GERD: gastroesophageal reflux; OSA: obstructive sleep apnea; PPI: proton pump inhibitor. *p value < 0.05