Table 1.
Pre-operative patient characteristics stratified by sTNFR1 tertiles in TRIBE-AKI
| Characteristic | sTNFR1 | ||||
|---|---|---|---|---|---|
| All (n = 1393) | Pre-op Tertile 1 24–6467 pg/mL (n = 464) |
Pre-op Tertile 2 6471–8964 pg/mL (n = 465) |
Pre-op Tertile 3 8966–100,000 pg/mL (n = 464) | P value | |
| Age, mean (at time of surgery) | 71.9 ± 9.7 | 69.2 ± 10.1 | 72.5 ± 9.8 | 73.8 ± 8.5 | < 0.001 |
| White | 1.3 (94.2%) | 436 (94.0%) | 444 (95.5%) | 432 (93.1%) | 0.3 |
| Male | 963 (69.1%) | 340 (73.3%) | 321 (69.0%) | 302 (65.1%) | 0.03 |
| Diabetes | 539 (38.7%) | 165 (35.6%) | 170 (36.6%) | 204 (44.0%) | 0.02 |
| Hypertension | 1,112 (79.8%) | 348 (75.0%) | 374 (80.4%) | 390 (84.1%) | 0.003 |
| EF < 35% or grade 3 or 4 LV dysfunction | 136 (9.8%) | 43 (9.3%) | 47 (10.1%) | 46 (9.9%) | 0.9 |
| Myocardial infarction | 357 (25.6%) | 104 (22.4%) | 119 (25.6%) | 134 (28.9%) | 0.3 |
| Congestive heart failure | 314 (22.5%) | 76 (16.4%) | 94 (20.2%) | 144 (31.0%) | < 0.001 |
| Mean Preoperative serum Cr, mg/dL | 1.1 ± 0.3 | 0.9 ± 0.2 | 1 ± 0.21 | 1.3 ± 0.4 | < 0.001 |
| Mean Preoperative eGFR, mL/min/1.73m2 | 68.2 ± 19.2 | 80 ± 14.4 | 70.6 ± 15.5 | 53.9 ± 17.6 | < 0.001 |
| CKD stage ≥ 3 | 465 (33.4%) | 35 (7.5%) | 128 (27.5%) | 302 (65.4%) | < 0.001 |
| Mean Urine Albumin to Cr ratio, mg/g | 0.1 ± 1.4 | 0.04 ± 0.10 | 0.1 ± 0.1 | 0.3 ± 2.5 | 0.03 |
| Surgery type | 0.06 | ||||
| CABG and valve | 310 (22.3%) | 91 (19.6%) | 102 (21.9%) | 117 (25.2%) | |
| Other | 19 (1.3%) | 8 (1.7%) | 5 (1.0%) | 6 (1.3%) | |
| CABG only | 679 (48.7%) | 234 (50.4%) | 245 (52.7%) | 200 (43.1%) | |
| Valve only | 385 (27.6%) | 131 (28.2%) | 113 (24.3%) | 141 (30.4%) | |
| Nonelective surgery | 1163 (83.5%) | 414 (89.2%) | 401 (86.2%) | 348 (75.0%) | < 0.001 |
AKI acute kidney injury defined as (0.3 mg/dl or 50% rise in serum creatinine), eGFR estimated glomerular filtration rate calculated using CKD-EPI equation, CKD chronic kidney disease, CABG coronary artery bypass grafting, CPB cardiopulmonary bypass, ICU intensive care unit. To covert serum creatinine value from mg/dl to µmol/L please multiple by 88.4.
†Albuminuria defined as Urine Albumin to Creatinine ratio > 30 mg/g