Table 2.
Hazard Ratios for mortality, cardiovascular and kidney events in TRIBE-AKI
| Biomarker | Range, pg/mL (Min, Max) | All-cause mortality | Cardiovascular Events | Chronic Kidney Disease Events | |||
|---|---|---|---|---|---|---|---|
| Event rate (95% CI) per 1000 PY | Adjusted* Hazard Ratio (95% CI) | Event rate (95% CI) per 1000 PY | Adjusted* Hazard Ratio (95% CI) | Event rate (95% CI) per 1000 PY | Adjusted* Hazard Ratio (95% CI) | ||
| sTNFR1 (pg/mL) | Loge Transformed | 53.7 (49.0, 58.8) | 3.0 (2.3–4.0) | 34.6 (30.7, 38.9) | 2.1 (1.5–3.1) | 55.4 (49.1, 62.5) | 2.2 (1.5–3.1) |
|
Tertile1 (957, 2066) |
32.2 (26.2, 39.5) | 1 (reference) | 22.9 (17.8, 29.4) | 1 (reference) | 42.0 (33.4, 52.8) | 1 (reference) | |
|
T2 (2067, 2829) |
44.7 (37.5, 53.2) | 1.2 (0.9–1.6) | 29.0 (23.2, 36.3) | 1.1 (0.8–1.5) | 55.5 (45.1, 68.2) | 1.4 (1.0–1.9) | |
|
T3 (2831, 4162) |
87.2 (76.3, 99.6) | 2.1 (1.5–2.8) | 55.0 (46.0, 65.9) | 1.7 (1.1–2.5) | 69.9 (56.7, 86.1) | 2.0 (1.4–3.0) | |
| sTNFR2 (pg/mL) | Loge Transformed | 53.7 (49.0, 58.8) | 2.3 (1.8–2.9) | 34.6 (30.7, 38.9) | 1.9 (1.4–2.6) | 55.4 (49.1, 62.5) | 1.9 (1.3–2.7) |
|
T1 (2022, 4756) |
31.4 (25.6, 38.6) | 1 (reference) | 24.7 (19.4, 31.5) | 1 (reference) | 48.4 (39.0, 60.1) | 1 (reference) | |
|
T2 (4758, 6651) |
47.1 (39.7, 55.8) | 1.3 (1.0–1.8) | 26.2 (20.6, 33.2) | 0.9 (0.6–1.3) | 53.8 (43.5, 66.7) | 1.1 (0.8–1.5) | |
|
T3 (6652, 9693) |
85.7 (74.9, 98.0) | 2.1 (1.6–2.9) | 56.0 (46.9, 66.9) | 1.6 (1.1–2.3) | 62.2 (50.3, 77.0) | 1.3 (0.9–2.0) | |
|
KIM-1 (pg/mL) |
Loge Transformed | 53.7 (49.0, 58.8) | 2.0 (1.6–2.4) | 34.6 (30.7, 38.9) | 1.6 (1.2–2.1) | 55.4 (49.1, 62.5) | 1.7 (1.3–2.3) |
|
T1 (42.0, 205.3) |
24.7 (19.6, 31.1) | 1 (reference) | 18.0 (13.6, 23.7) | 1 (reference) | 36.8 (28.8, 47.1) | 1 (reference) | |
|
T2 (205.4, 290.0) |
54.9 (46.8, 64.3) | 1.8 (1.3–2.4) | 39.3 (32.2, 47.9) | 1.9 (1.3–2.7) | 55.7 (45.2, 68.7) | 1.6 (1.1–2.2) | |
|
T3 (290.2, 8599.8) |
85.3 (74.5, 97.7) | 2.7 (2.0–3.7) | 49.8 (41.2, 60.1) | 2.1 (1.4–3.0) | 75.0 (61.7, 91.1) | 2.2 (1.6–3.2) | |
*Adjusted for recipient Age (per year), recipient gender, white race (Yes/No), non-elective surgery, surgery type, pre-op eGFR, diabetes, hypertension, CHF, history of MI, pre-op urine albumin and urine creatinine, clinical site