Table 3.

C-index of Clinical Variables and Biomarkers

Outcome	Model					Clinical + sTNFR1 + KIM1	Clinical + sTNFR2 + KIM1
	Clinical Alone	Clinical + sTNFR1	Clinical + sTNFR2	Clinical + KIM1	Clinical  + All 3 Markers
CKD events	0.626	0.648 (0.0002)	0.635 (0.13)	0.644 (< 0.0001)	0.652 (sTNFR1 0.0004, sTNFR2 0.0135, KIM1 < 0.0001)	0.656 (sTNFR1 0.0103, KIM1 0.0002)	0.646 (sTNR2 0.76, KIM1 < 0.0001)
CVD	0.669	0.678 (0.0049)	0.676 (0.0075)	0.689 (< 0.0001)	0.692 (sTNFR1 0.42, sTNFR2 0.56, KIM1 0.0015)	0.692 (sTNFR1 0.09, KIM1 0.0011)	0.691 (sTNR2 0.11, KIM1 0.0009)
Death	0.667	0.685 (< 0.0001)	0.689 (< 0.0001)	0.696 (< 0.0001)	0.703 (sTNFR1 0.32, sTNFR2 0.13, KIM1 < 0.0001)	0.700 (sTNFR1 0.0028, KIM1 < 0.0001)	0.704 (sTNR2 0.0014, KIM1 < 0.0001)

P values for association of biomarker in parentheses

CKD chronic kidney disease, CI confidence interval, CVD cardiovascular disease

Clinical model = Age (per year), recipient gender, white race (Yes/No), non-elective surgery, surgery type, pre-op eGFR, diabetes, hypertension, CHF, history of MI, pre-op urine albumin and urine creatinine, and center