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. 2022 Dec 21;9:1341–1352. doi: 10.2147/JHC.S388077

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© 2022 Duan et al.

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Nrf2 knockdown inhibited the migration of 5-FU-resistant HCC cells by inactivating HIF-1α signaling. (A and B) Western blotting analysis of HIF-1α levels in Nrf2-knockdown cells (A), Nrf2-overexpressed cells (B), and control cells. (C) HIF-1α was knocked down in SNU-387/5-FU and Hep3B/5-FU cells. (D–G) Migration was determined using the Transwell assay in (D and E) SNU-387/5-FU and (F and G) Hep3B/5-FU cells. Scale bar = 100 μm. All data are expressed as mean ± SEM. *P < 0.05; **P < 0.01; versus the control group. ^#P < 0.05 versus the indicated groups.