TABLE 6.
Comparison of genotypic compositions of B. burgdorferi strain B31 P48 clones following either in vitro cultivation or in vivo selection in C3H/HeN mice
| Plasmidd | Presencea in P48
|
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| In vitrob (n = 49)c
|
In vivo
|
|||||||||
| + | − | Skin (OMS)e (n = 20)
|
Bladder (OMB)e(n = 20)
|
Joint (OMJ)e(n = 99)
|
Total (n = 139)
|
|||||
| + | − | + | − | + | − | + | − | |||
| cp9 | 4.1 (2) | 95.9 (47) | 0 (0)f | 100 (20) | 0 (0)f | 100 (20) | 1 (1)i | 99 (98) | 0.7 (1) | 99.3 (138) |
| lp25 | 10.2 (5) | 89.8 (44) | 100 (20)g | 0 (0) | 100 (20)g | 0 (0) | 100 (99)g | 0 (0) | 100 (139) | 0 (0) |
| lp28-1 | 69.4 (34) | 30.6 (15) | 85 (17)g | 15 (3) | 100 (20)g | 0 (0) | 75.7 (75)i | 24.3 (24) | 80.6 (112) | 19.4 (27) |
| lp28-4 | 10.2 (5) | 89.8 (44) | 0 (0)h | 100 (20) | 10 (2)h | 90 (18) | 4 (3)f | 96 (96) | 3.6 (5) | 96.4 (134) |
The values indicate the percentage of samples that contained the given plasmid (+) versus the percentage that lacked the given plasmid (−). Actual numbers of samples are indicated parenthetically.
Reflects the eight different genotypic variants shown in Table 3.
Number of individual colonies (clones) tested.
Plasmids lost either individually or as a group in the genotypic variants shown in Table 3.
See Table 1.
χ2 analysis indicates a selection (P < 0.05) against this plasmid when this tissue is compared to the in vitro sample.
χ2 analysis indicates a significant selection (P < 0.001) for this plasmid when this tissue is compared to the in vitro sample.
χ2 analysis indicates a significant selection (P < 0.001) against this plasmid when this tissue is compared to the in vitro sample.
χ2 analysis indicates no significant selection for or against this plasmid when this tissue is compared to the in vitro sample.