Table 1.

Differences and similarities between the estimands of several treatments for the same disease studied within the same trial or master protocol

Estimand attribute	Guidance
A. Treatment	“Different for each treatment investigated but common comparator”
B. Population	“Similar for each treatment investigated”
C. Variable	Could vary with the drug as different treatments could target different aspects of the disease (e.g., remission, disease severity, pain, etc.)
D. Intercurrent events	Population‐specific IEs would be similar (e.g., change in background medication), whereas treatment‐specific IEs would vary
E. Population‐level summary	Would change with the variable

IEs, intercurrent events.