TABLE 2.
Top differentially methylated CpGs associated with cortisol levels
| Cate model b | ||||||
|---|---|---|---|---|---|---|
| CpG | Location (hg19) | Gene | r | β coef. | P | adj.p |
| cg15321696 | chr10:14424332 | FRMD4A | −0.33 | −0.001 | 1.25 × 10−07 | 0.078 |
| cg18105800 | chr3:33420182 | FBXL2 | +0.33 | +0.0006 | 6.88 × 10−07 | 0.11 |
| cg00986889 | chr12:6697033 | CHD4 | −0.25 | +0.0004 | 6.67 × 10−07 | 0.11 |
| cg15920527 | chr3:14648593 | a CCDC174 | −0.27 | −0.0007 | 5.35 × 10−07 | 0.11 |
Abbreviations: adj.p = multiple testing adjusted p‐value; β Coef., Regression coefficient; CCDC174, Coiled‐Coil Domain Containing 174; CHD4, Chromodomain Helicase DNA Binding Protein 4; CpG, cytosine‐phosphate‐guanine; FBXL2, F‐Box And Leucine Rich Repeat Protein 2; FRMD4A, FERM Domain Containing 4A; hg19, Homo sapiens (human) genome assembly GRCh37; r, correlation coefficient.
a
in Gene category denotes that probe is upstream from the gene body/transcription site.
b
using m values, adjusted for cell type, child age and sex, maternal age, maternal education, maternal marital status, maternal living area, prenatal smoking, batch, and BH method for multiple testing.