TABLE 1.
Clinical and pathological features of the patients with rectal cancer who underwent preoperative chemoradiotherapy (CRT)
| Variables | Low response (n = 21) | High response (n = 26) | p‐value | |
|---|---|---|---|---|
| Clinical variables before CRT | ||||
| Age | 61 (38–73) | 63 (48–76) | 0.720 | |
| Gender | (M/F) | 13/8 | 23/3 | 0.043 |
| Macroscopic appearance | (1/2/3) | 0/20/1 | 2/22/2 | 0.369 |
| Location | (Ra,Rab/Rb,RbP) | 1/20 | 1/25 | 1.000 |
| Tumour length | (cm) | 7.1 (3.1–10.2) | 5.8 (2.8–14.6) | 0.454 |
| Circumferential rate | (%) | 70% (33%–100%) | 67% (20%–100%) | 0.578 |
| Depth of invasion | (cT: ≤3/4) | 14/7 | 24/2 | 0.058 |
| Nodal metastasis | (cN: 0/1≤) | 7/14 | 6/20 | 0.520 |
| Clinical stage | (cStage: 2/3) | 7/14 | 6/20 | 0.520 |
| Histology | (tub, pap/por) | 20/1 | 25/1 | 1.000 |
| Serum CEA | (ng/ml) | 4.5 (0.8–42.4) | 3.7 (0.8–23.0) | 0.336 |
| Serum CA19‐9 | (U/ml) | 14.0 (1.0–205) | 11.5 (2.0–1650) | 0.822 |
| Surgery a | (LAR/APR/ISR/TPE) | 10/10/0/1 | 11/13/1/0 | 0.931 |
| Pathological variables after CRT a | ||||
| Depth of invasion | (pt: ≤1/2≤) | 0/21 | 9/16 | 0.002 |
| Nodal metastasis | (pn: 0/1≤) | 10/11 | 18/7 | 0.137 |
| Lymphatic invasion | (Negative/positive) | 10/11 | 23/2 | 0.001 |
| Venous invasion | (Negative/positive) | 3/18 | 19/6 | <0.001 |
| Stage | (pStage: ≤1/2≤) | 1/20 | 15/10 | <0.001 |
Note: All the patients completed neoadjuvant CRT with 50.5 Gy irradiation and oral capecitabine 1650 mg/m2/days. p‐values were evaluated with Fisher's exact test or Mann–Whitney's test.
Abbreviations: APR, abdominoperineal resection; ISR, intersphincteric resection; LAR, low anterior resection; TPE, total pelvic exenteration.
a
Surgery was performed in 46 patients and their pathological data are presented.