TABLE 2.
The number of leucocyte subsets in circulating blood before and after preoperative chemoradiotherapy (CRT) in 47 patients with locally advanced rectal cancer
| Cell counts of lymphocyte or monocyte subsets (/mm3) | Before CRT | After CRT | ||||
|---|---|---|---|---|---|---|
| Low response (n = 21) | High response (n = 26) | p‐value | Low response (n = 21) | High response (n = 26) | p‐value | |
| Neutrophils | 4128 ± 325 | 4026 ± 292 | 0.827 | 3250 ± 268 | 3171 ± 246 | 0.829 |
| Lymphocytes | 1497 ± 6125 | 1568 ± 113 | 0.678 | 685 ± 74.9 | 881 ± 68.6 | 0.030 |
| CD3(+)CD4(+) T cell | 519 ± 60.8 | 505 ± 54.7 | 0.868 | 173 ± 19.8 | 222 ± 18.5 | 0.041 |
| CD3(+)CD8(+) T cell | 313 ± 34.5 | 323 ± 31.1 | 0.833 | 146 ± 25.5 | 186 ± 23.9 | 0.260 |
| CD3(+)CD56(+) NKT cell | 73 ± 10.7 | 72 ± 9.7 | 0.94 | 46 ± 5.9 | 41 ± 5.5 | 0.467 |
| CD3(−)CD16(+) NK cell | 210 ± 25.3 | 176 ± 28.1 | 0.362 | 118 ± 36.2 | 194 ± 33.8 | 0.131 |
| Monocytes | 467 ± 35.5 | 470 ± 31.9 | 0.948 | 408 ± 26.7 | 423 ± 26.8 | 0.684 |
| Classical monocyte | 224 ± 21.7 | 212 ± 19.6 | 0.692 | 214 ± 20.9 | 215 ± 19.6 | 0.940 |
| Intermediate monocyte | 28 ± 3.3 | 26 ± 3.3 | 0.628 | 33 ± 4.6 | 36 ± 4.3 | 0.648 |
| Patrolling monocyte | 62 ± 7.3 | 60 ± 6.5 | 0.851 | 76 ± 9.0 | 72 ± 8.4 | 0.706 |
| NLR | 3.21 ± 0.31 | 2.80 ± 0.28 | 0.327 | 5.21 ± 0.50 | 4.10 ± 0.46 | 0.108 |
| LMR | 3.40 ± 0.26 | 3.50 ± 0.23 | 0.761 | 1.77 ± 0.19 | 2.11 ± 0.18 | 0.048 |
Note: Data show mean ± SEM, p‐values calculated with Student's t‐test. Classical, intermediate and patrolling monocytes were determined as CD14high(+) CD16(−), CD14mid(+) CD16(+) and CD14low(+) CD16(+) phenotype, respectively.
Abbreviations: LMR, lymphocyte monocyte ratio; NLR, neutrophil lymphocyte ratio.