Table 1.
Patient, tumour and hospital characteristics of untreated patients diagnosed with non‐metastatic muscle‐invasive bladder cancer over time (2005–2019).
| Total | Year of diagnosis | ||||||
|---|---|---|---|---|---|---|---|
| 2005–2007 | 2008–2010 | 2011–2013 | 2014–2016 | 2017–2019 | P value for trend * | ||
| Total, N (%) | 3236 (100.0) | 648 (20.0) | 684 (21.1) | 571 (17.6) | 680 (21.0) | 653 (20.2) | |
| Patient characteristics | |||||||
| Gender, n (%) | 0.5378 | ||||||
| Male | 2282 (70.5) | 446 (68.8) | 491 (71.8) | 393 (68.8) | 494 (72.6) | 458 (70.1) | |
| Female | 954 (29.5) | 202 (31.2) | 193 (28.2) | 178 (31.2) | 186 (27.4) | 195 (29.9) | |
| Age at diagnosis (median, IQR), years |
82.0 75.0–86.0 |
81.0 74.0–85.0 |
81.0 74.0–86.0 |
82.0 75.0–86.0 |
83.0 76.0–87.0 |
83.0 76.0–87.0 |
<0.0001 |
| Age at diagnosis, n (%) | 0.0986 | ||||||
| <60 years | 138 (4.3) | 31 (4.8) | 35 (5.1) | 20 (3.5) | 32 (4.7) | 20 (3.1) | |
| 60–70 years | 319 (9.9) | 74 (11.4) | 70 (10.2) | 61 (10.7) | 58 (8.5) | 56 (8.6) | |
| 70–80 years | 842 (26.0) | 183 (28.2) | 191 (27.9) | 139 (24.3) | 169 (24.9) | 160 (24.5) | |
| ≥80 years | 1937 (59.9) | 360 (55.6) | 388 (56.7) | 351 (61.5) | 421 (61.9) | 417 (63.9) | |
| Age at diagnosis (dichotomous), n (%) | 0.0049 | ||||||
| <75 years | 777 (24.0) | 175 (27.0) | 178 (26.0) | 132 (23.1) | 152 (22.4) | 140 (21.4) | |
| ≥75 years | 2459 (76.0) | 473 (73.0) | 506 (74.0) | 439 (76.9) | 528 (77.6) | 513 (78.6) | |
| SES, n (%) | 0.1222 | ||||||
| Low | 469 (14.5) | 136 (21.0) | 83 (12.1) | 77 (13.5) | 97 (14.3) | 76 (11.6) | |
| Middle | 1291 (39.9) | 253 (39.0) | 299 (43.7) | 237 (41.5) | 263 (38.7) | 239 (36.6) | |
| High | 888 (27.4) | 149 (23.0) | 180 (26.3) | 161 (28.2) | 196 (28.8) | 202 (30.9) | |
| Unknown | 588 (18.2) | 110 (17.0) | 122 (17.8) | 96 (16.8) | 124 (18.2) | 136 (20.8) | |
| Weighted CCI score ** , n (%) | 0.0056 | ||||||
| 0 | 184 (23.7) | 33 (36.3) | 24 (31.6) | 13 (18.8) | 21 (23.1) | 93 (20.6) | |
| 1 | 213 (27.4) | 27 (29.7) | 19 (25.0) | 19 (27.5) | 26 (28.6) | 122 (27.1) | |
| 2 | 153 (19.7) | 17 (18.7) | 12 (15.8) | 17 (24.6) | 19 (20.9) | 88 (19.5) | |
| 3 or more | 166 (21.3) | 13 (14.3) | 20 (26.3) | 18 (26.1) | 16 (17.6) | 99 (22.0) | |
| Unknown | 62 (8.0) | 1 (1.1) | 1 (1.3) | 2 (2.9) | 9 (9.9) | 49 (10.9) | |
| Tumour characteristics, n (%) | |||||||
| cT stage (TNM) | 0.0007 | ||||||
| cT2 | 2525 (78.0) | 507 (78.2) | 566 (82.7) | 453 (79.3) | 520 (76.5) | 479 (73.4) | |
| cT3 | 402 (12.4) | 75 (11.6) | 58 (8.5) | 69 (12.1) | 88 (12.9) | 112 (17.2) | |
| cT4a | 309 (9.5) | 66 (10.2) | 60 (8.8) | 49 (8.6) | 72 (10.6) | 62 (9.5) | |
| Focality of the tumour | <0.0001 | ||||||
| Multifocal | 667 (20.6) | 116 (17.9) | 132 (19.3) | 112 (19.6) | 156 (22.9) | 151 (23.1) | |
| Unifocal | 2240 (69.2) | 423 (65.3) | 481 (70.3) | 415 (72.7) | 463 (68.1) | 458 (70.1) | |
| Unknown | 329 (10.2) | 109 (16.8) | 71 (10.4) | 44 (7.7) | 61 (9.0) | 44 (6.7) | |
| Localization of the tumour, n (%) | 0.0063 | ||||||
| Trigone | 256 (7.9) | 39 (6.0) | 61 (8.9) | 42 (7.4) | 47 (6.9) | 67 (10.3) | |
| Dome | 113 (3.5) | 19 (2.9) | 25 (3.7) | 23 (4.0) | 23 (3.4) | 23 (3.5) | |
| Right or left wall | 693 (21.4) | 140 (21.6) | 146 (21.3) | 120 (21.0) | 135 (19.9) | 152 (23.3) | |
| Anterior wall | 85 (2.6) | 22 (3.4) | 18 (2.6) | 13 (2.3) | 12 (1.8) | 20 (3.1) | |
| Posterior wall | 191 (5.9) | 57 (8.8) | 25 (3.7) | 35 (6.1) | 42 (6.2) | 32 (4.9) | |
| Bladder neck | 134 (4.1) | 27 (4.2) | 20 (2.9) | 19 (3.3) | 39 (5.7) | 29 (4.4) | |
| Left or right ureteric orifice | 167 (5.2) | 34 (5.2) | 41 (6.0) | 31 (5.4) | 27 (4.0) | 34 (5.2) | |
| Overlapping localizations | 1161 (35.9) | 227 (35.0) | 268 (39.2) | 215 (37.7) | 249 (36.6) | 202 (30.9) | |
| Unknown | 436 (13.5) | 83 (12.8) | 80 (11.7) | 73 (12.8) | 106 (15.6) | 94 (14.4) | |
| Hospital characteristics | |||||||
| Type of hospital (diagnosis), n (%) | 0.4210 | ||||||
| Community hospital | 1408 (43.5) | 269 (41.5) | 294 (43.0) | 264 (46.2) | 286 (42.1) | 295 (45.2) | |
| Non‐university referral hospital | 1688 (52.2) | 354 (54.6) | 357 (52.2) | 277 (48.5) | 364 (53.5) | 336 (51.5) | |
| University hospital | 140 (4.3) | 25 (3.9) | 33 (4.8) | 30 (5.3) | 30 (4.4) | 22 (3.4) | |
CCI, Charlson Comorbidity Index; IQR, interquartile range; SES, socioeconomic status.
*
P value for trend (two‐sided) was calculated using linear regression for parametric continuous variables, Cochran–Armitage trend test for binary variables and Cochran–Mantel–Haenszel test for categorical variables with more than two categories.
**
Before November 2017, CCI score was only available for the southern region of the Netherlands.