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. 2022 Apr 22;97(5):532–540. doi: 10.1111/cen.14739

Table 5.

Summary of findings reported in the 11 papers included in the systematic review but not in the meta‐analyses

Ref First author Main findings
[20] Zhu Tumour size >40 mm, capsular invasion, metastatic cervical lymph nodes positively correlated with the risk of postoperative recurrence of MTC.
[28] Guo In presence of cystic change, circumscribed margin, regular shape, no calcification, no rich vascularity, and normal cervical lymph nodes, MTC is easily misdiagnosed as benign by US.
[30] Wang The higher frequency US presentation of MTC was the low‐echo tumour in round or quasi‐circular shape, with obscure boundary and often combined with rough calcification.
[33] Bao The common US findings for MTC were solid composition, hypoechogenicity, regular sharp, well‐defined margin, and calcifications.
[34] Zhou Sonographic features of MTC are similar to those of small papillary carcinomas but greatly different from those of large papillary ones.
[36] Sesti US can detect recurrent MTCs with an accuracy positively correlated with calcitonin levels.
[37] Choi The predominant US findings of MTC included solid internal content, round‐to‐oval shape, smooth margins, hypoechogenicity, and micro‐ or macro‐calcifications.
[38] Lee MTCs differ from PTCs in size, presence of a cystic change, and echotexture.
[39] Cai The typical sonographic features of MTC are hypoechogenicity, predominantly solid, irregularly shaped with intranodular micro‐ or macro‐calcifications.
[40] Kim US findings for MTC are not greatly different from PTC except for the prevalence of an ovoid‐to‐round shape.
[43] Saller Conventional US reveals a combination of hypoechogenicity, intranodular calcifications, and absence of ‘halo sign’ in the vast majority of MTC.

Abbreviations: MTC, medullary thyroid carcinoma; PTC, papillary thyroid carcinoma; US, ultrasound.