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. 2022 May 9;114(16):1037–1055. doi: 10.1002/bdr2.2019

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Published 2022. This article is a U.S. Government work and is in the public domain in the USA. Birth Defects Research published by Wiley Periodicals LLC.

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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Comparison of equivalent administered doses (EADs) to oral rat lowest effect levels (LELs) for selected valproic acid analogues. The figure represents data provided in Table 3. EAD values predicted from devTOX quickPredict assay nominal developmental toxicity potential concentrations (open symbols) and free medium concentration (filled symbols) using one‐compartment population‐based pharmacokinetic (triangles) or httk.PBTK model (circles) are compared to the lowest and highest rat LELs (star and cross, respectively). Dashed lines highlight the range from lowest to highest in vivo LELs. The chemicals are ordered based on their lowest LELs, from low (left) to high (right). Whether predicted (p) or experimental (e) Cl_int values were used to generate EAD is indicated parenthetically on x‐axis labels.