TABLE 2.
Summary of CSF markers from included studies
| CSF marker | Function | Localization |
|---|---|---|
| Alpha‐Synuclein | Regulation of synaptic vesicle trafficking | Pre‐synaptic |
| Beta‐Synuclein | Unknown | Pre‐synaptic |
| Contactin‐2 |
Axonal guidance Axonal fasciculation |
Pre‐synaptic Axonal |
| GAP‐43 |
Axonal outgrowth Synaptic plasticity |
Pre‐synaptic |
| NfH | Neuronal structure | Axonal |
| NfL | Neuronal structure | Axonal |
| Ng |
Calmodulin‐binding LTP signalling |
Post‐synaptic |
| NPTX1 |
Synaptic plasticity Facilitates excitatory synapse formation |
Pre‐synaptic |
| NPTX2 |
Synaptic plasticity Facilitates excitatory synapse formation |
Pre‐synaptic |
| NPTXR |
Synaptic plasticity Facilitates excitatory synapse formation |
Trans‐synaptic |
| Nrg1 | Synaptic plasticity | Pre‐synaptic |
| SNAP‐25 | SNARE | Pre‐synaptic |
| Synaptotagmin | Calcium sensor | Pre‐synaptic |
| VILIP‐1 | Calcium sensor | Neuronal |
Abbreviations: CSF, cerebrospinal fluid; GAP‐43, growth‐associated protein 43; NfH, neurofilament‐heavy; NfL, neurofilament‐light; Ng, neurogranin; NPTX1, neuronal pentraxin I; NPTX2, neuronal pentraxin 2; NPTXR, neuronal pentraxin receptor; Nrg1, neuregulin‐1; SNAP‐25, synaptosomal‐associated protein 25; VILIP‐1, visinin‐like protein‐1.