TABLE 4.
Summary of results grouped by CSF marker and diagnosis
| CSF marker | AD | MCI | CU | AD, MCI, CU Aβ+ | AD, MCI, CU Aβ‐ | AD, MCI, CU | MCI, CU | CUf | FTD‐related syndromes | DLB | VaD | EAD | PSP | CBS | Other |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| NfL |
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| Ng |
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| α‐Syn |
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| β‐Syn |
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| Contactin‐2 |
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| GAP‐43 |
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| NPTX1/2/R |
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| Nrg1 |
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| SNAP‐25 |
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| Synaptotagmin‐1 |
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| VILIP‐1 |
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Note: Blue inverted triangles (
) indicate a significant negative association, and green triangles (
), respectively, indicate a significant positive association between CSF marker levels and neuropsychological performance. Black circles indicate no significant associations. Numeric value within shape corresponds to number of studies with this finding.
Abbreviations: AD, Alzheimers disease; Aβ‐, amyloid beta negative; Aβ+, amyloid beta positive; CBS, corticobasal syndrome; CU, cognitively unimpaired; CUf, cognitively unimpaired with familial history of AD; DLB, dementia with Lewy bodies; EAD, early‐onset Alzheimers disease; FTD, frontotemporal dementia; GAP‐43, growth‐associated protein 43; MCI, mild cognitive impairment; NfL, neurofilament‐light; Ng, neurogranin; NPTX1/R, neuronal pentraxin 1/receptor; Nrg1, neuregulin‐1; PSP, progressive supranuclear palsy; SNAP‐25, synaptosomal‐associated protein 25; VaD, vascular dementia; VILIP‐1, visinin‐like protein 1; α‐syn, alpha‐synuclein; β‐syn, beta‐synuclein.