Table 5.
Fine and Gray Regression Analysis Seeking Risk Factors at Diagnosis for Developing Splenic Infarction (n=347).
| Univariate analysis | Multivariate analysis | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HR | 95% CI | p value | HR | 95% CI | p value | |||||||
| Age >60yr | 0.58 | 0.21-1.63 | 0.300 | - | - | - | ||||||
| Male | 1.48 | 0.49-4.42 | 0.486 | - | - | - | ||||||
| Palpable splenomegaly | 14.35 | 5.52-46.09 | <0.001 | 14.89 | 4.00-55.35 | <0.001 | ||||||
| WBC >12.0 ×109/L | 0.52 | 0.25-2.03 | 0.521 | - | - | - | ||||||
| WBC >25.0 ×109/L | 3.04 | 0.63-14.62 | 0.166 | - | - | - | ||||||
| Monocyte >1.0 ×109/L | 2.32 | 0.71-7.60 | 0.165 | |||||||||
| Platelet >1,000 ×109/L | 0.25 | 0.93-1.90 | 0.177 | - | - | - | ||||||
| LDH >1.5 ×UNL | 3.46 | 1.21-9.88 | 0.020 | 2.73 | 0.88-8.45 | 0.082 | ||||||
| Positive JAK2V617F | 1.25 | 0.04-4.61 | 0.736 | - | - | - | ||||||
| Positive CALR mutation | 0.53 | 0.06-5.07 | 0.580 | |||||||||
| PV | 1.51 | 0.53-4.26 | 0.440 | - | - | - | ||||||
| pre-PMF | 2.66 | 0.81-8.74 | 0.108 | - | - | - | ||||||
| PMF | 4.11 | 1.23-12.78 | 0.022 | 0.61 | 0.13-2.92 | 0.538 | ||||||
| Hypertension | 0.41 | 0.13-1.30 | 0.129 | - | - | - | ||||||
| Diabetes mellitus | 1.05 | 0.29-3.82 | 0.945 | - | - | - | ||||||
| Chronic kidney disease | 0.67 | 0.15-3.05 | 0.604 | - | - | - | ||||||
| Smoking | 1.71 | 0.59-4.95 | 0.320 | - | - | - | ||||||
| Thrombosis before or at diagnosis | 0.4 | 0.0-91.81 | 0.235 | - | - | - | ||||||
HR: hazard ratio, CI: confidence interval, LDH: lactate dehydrogenase, UNL: upper normal limit, PV: polycythemia vera, pre-PMF: prefibrotic/early primary myelofibrosis