Table 1.
Application of PMCA for ultrasensitive prion detection in body fluids of patients affected by vCJD
| Sample | Disease group Npositive/Ntotal | Control group Npositive/Ntotal | Reported sensitivity | Reported specificity | Reference |
|---|---|---|---|---|---|
| Blood | 3/4 | 0/141 | 75% | 100% | Lacroux et al (2014) |
| Blood | 18/18 | 1/238 | 100% |
99.2% (analytical) 100% (diagnostic) |
Bougard et al (2016) |
| Blood | 14/14 | 0/153 | 100% | 100% | Concha-Marambio et al (2016) |
| Urine | 13/14 | 0/224 | 92.9% | 100% | Moda et al (2014) |
| CSF | 40/41 | 0/57 | 97.6% | 100% | Bougard et al (2018) |
| CSF | 15/15 | 0/41 | 100% | 100% | Barria et al (2018) |