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. 2022 Dec 12;9:1069797. doi: 10.3389/fnut.2022.1069797

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Copyright © 2022 Zhu, Xu, Liu, Guan, Xu, Zhao and Ge.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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NFEG-microgel changed the diversity and composition of gut microbiota in HFD-fed rats. (A) α-diversity index (observed, Chao1, Shannon, and Simpson index). (B) Bray–Curtis PCoA plot based on the OTU abundance of each rat. (C) Heat map of bacterial taxonomic profiling at the genus level of intestinal bacteria based on each rat from different groups: NC group (A1–A5), HFD + NF group (B1–B5), HFD + NFEG group (C1–C5), HFD group (D1–D5), HFD + EGCG group (E1–E5), and HFD + MG group (M1–M5). Linear discriminant analysis (LDA) scores (D) and cladogram (E) generated from linear discriminate analysis effect size (LEfSe) analysis, showing the biomarker taxa (LDA score of > 4 and a significance of P < 0.05 determined by the Wilcoxon signed-rank test). Significant difference was indicated with the sign *P < 0.05 and ^**P < 0.01.