Table 1.

Recommended NP cut-offs for acute HF diagnosis^*

Cut-off to make a decision	Cut-off points
	BNP, pg/mL	NT-proBNP, pg/mL			MR-proANP, pmol/L
	All ages	Aged <50 yr	Aged 50–75 yr	Aged >75 yr	All ages
Acute/acutely decompensated HF
Rule out HF	< 100	< 300	< 300	< 300	< 40
Mild probability (“grey” zone)	100–400	300–450	300–900	300–1,800	40–120
Rule in HF	> 400	> 450	> 900	> 1,800	> 120
Stable HF
Rule out HF	< 35	< 125	< 125	≥ 125	< 40
Mild probability (“grey” zone)	35–150	125–600	125–600	125–600	40–120
Rule in HF	> 150	> 600	> 600	> 600	> 120

*Data were obtained from references [25-29].

Abbreviations: NP, natriuretic peptide; HF, heart failure; BNP, brain natriuretic peptide; NT-proBNP, N-terminal pro-B-type natriuretic peptide; MR-pro-ANP, mid-regional pro-atrial natriuretic peptide.