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. 2022 Dec 12;12:1068908. doi: 10.3389/fcimb.2022.1068908

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Copyright © 2022 Li, Zhao, Chen, Ni, Yu, Hu, Qin, Zhao, Peng, Lu, Gao and Sun

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(A) Genera showing variation at different time points. The Kruskal-Wallis test indicated significant differences between time points in both AD and HC. The dashed line indicates p = 0.05. (B-I) Relative abundances of significant taxa in AD and HC conditions across time points: (B) Neisseria, (C) Prevotella, (D) Lactobacillus, (E) Haemophilus, (F) Veillonella, (G) Cyanobacteria, (H) Sphaerochaeta, (I) Leptotrichia. *Wilcox Test indicated significant differences between different groups at one time point, Kruskal-Wallis test indicated significant differences between time points in either AD and HC. All p values are Bonferroni adjusted. * indicates p < 0.05, ** indicates p < 0.01, *** indicates p < 0.01. Data are expressed as the mean ± SEM (n=21-32).