Table 1. Gene expression of important glycemic markers measured in the medial basal hypothalamus and ileum.
Gene | Probe | Naïve-Chow | SCI-Chow | Naïve-HFD | SCI-HFD | Statistics |
---|---|---|---|---|---|---|
Mean ± SEM | Mean ± SEM | Mean ± SEM | Mean ± SEM | |||
Hypothalamic expression | ||||||
g6pd | Rn01529640_g1 | 100.0 ± 10.8 | 180.4 ± 25.6 | 79.7 ± 7.6 | 154.4 ± 11.1 | P(injury) < 0.001 |
gck | Rn00561265_m1 | 100.0 ± 10.2 | 149.2 ± 11.1 | 65.4 ± 4.2 | 141.4 ± 12.2 | P(injury) < 0.0001 |
glp1r | Rn00562406_m1 | 100.0 ± 15.2 | 162.8 ± 9.8 | 69.4 ± 9.1 | 145.2± 13.9 | P(injury) < 0.001 |
insr | Rn00690703_m1 | 100.0 ± 9.7 | 158.6 ± 6.4 | 75.1 ± 4.2 | 141.7± 9.1 | P(injury) < 0.001, P(diet) < 0.05 |
Ileal gene expression | ||||||
Gcg | Rn00562293_m1 | 100.0 ± 13.6 | 100.4 ± 7.8 | 104.0 ± 13.5 | 107.3 ± 14.8 | NS |
glp1r | Rn00562406_m1 | 100.0 ± 28.7 | 195.3 ± 76.2 | 138.0 ± 23.2 | 299.6 ± 50.5 | P(injury) < 0.05, P(diet) < 0.05 |
dpp4 | Rn00562910_m1 | 100.0 ± 20.5 | 182.5 ± 34.2 | 145.4 ± 35.9 | 163.0 ± 30.3 | NS |
Data are presented as mean ± SEM. Statistical significance was determined with two‐way analysis of variance for main effects.