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. 2022 Dec 12;13:1001778. doi: 10.3389/fmicb.2022.1001778

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Copyright © 2022 Jiang, Mao, Sun, Shi, Han, Zhang, Zhang, Wang, Hu, Zhang, Li and Han.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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YLZD improved the general status and mitigated hepatic lipid deposition. (A) Experimental design, (B) daily food intake, (C) body weight change, (D) Liver index = Liver weight/Body weight × 100, (E) Epididymal fat index = Epididymal fat weight/Body weight × 100, (F–H) The level of liver FFA, TG and TC, respectively, and (I) Representative images of HE and oil red staining livers (magnification, ×200). Control group, normal rats treated with distilled water; HFD group, HFD-induced liver injury rats treated with distilled water; YLZD group, HFD induced liver-damaged rats treated with YLZD 1.92 g/kg/day for 4 weeks. Values are represented as mean ± SEM (n = 6 rats/group). ^##p < 0.01, ^#p < 0.05 versus the Control group; ^**p < 0.01, ^*p < 0.05 versus the HFD group.