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. 2022 Dec 12;13:1092370. doi: 10.3389/fimmu.2022.1092370

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Copyright © 2022 Bishop, Caten, Nakaya and Suhrbier

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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IPA USRs heatmaps. The DEG lists for all groups were analyses by IPA and the top 50 USRs (significant in at least 1 group) plotted by molecule type and ranked by USR z-scores for Adults. Cytokine and Transcription regulator – USRs for Adults ranked by absolute z-score. Biologic and Chemical drug – ranked from highest negative z-score (most potent predicted inhibitor). Red arrows indicates compounds referred to in the text. Abbreviations: AC acti. pp - adenylate cyclase-activating polypeptide; intest. pep. intestinal peptide; APP der. comp. II - 6-aminopyrazolopyrimidine derivative compound II; h.r.p.- hormone related protein; HAART - highly active antiretroviral therapy; tyr.kin.inh. tyrosine kinase inhibitor.