Table 2.
Top 10 positive responses to small molecules of the Tocriscreen 2.0 library*.
| Single | Multiple | Average | Product name | Brief description |
|---|---|---|---|---|
| 1.66338483 | 1.64401141 | 1.65369812 | SGC 0946 | Highly potent and selective DOT1L inhibitor |
| 1.25677282 | 1.13910109 | 1.19793695 | Lonidamine | Mitochondrial hexokinase inhibitor |
| 1.14068884 | 1.13455792 | 1.13762338 | RN 1734 | Selective TRPV4 antagonist |
| 1.06569007 | 1.0916159 | 1.07865298 | SC 51089 | Selective EP1 receptor antagonist |
| 1.05430227 | 1.08110957 | 1.06770592 | Ro 25–6,981 maleate | Subtype-selective NR2B antagonist |
| 1.15839163 | 0.92565874 | 1.04202519 | Sarpogrelate hydrochloride | Selective 5-HT2A antagonist |
| 1.12654867 | 0.92557576 | 1.02606222 | BD 1047 dihydrobromide | Sigma1 selective antagonist |
| 0.95961761 | 1.06535556 | 1.01248658 | DSR 6434 | Potent TLR7 agonist |
| 0.84524024 | 1.16597778 | 1.00560901 | ML 193 | Potent, selective GPR55 antagonist |
| 0.72520622 | 1.27766667 | 1.00143644 | GC 1 | High-affinity thyroid receptor alpha (TRalpha) and TRbeta agonist |
*
The experimental design is as outlined in Methods and Figure 1. Day 18 DA neuron progenitors were plated and cultured for 10 days with DMSO only (Control) or treated with chemicals during the first 48 h (single treatment) or 8 days (continuous treatment). Luciferase readings were done at the end of the 10-day differentiation. Shown are the top 10 differential results in TH expression that was detected using the luciferase assay and normalized to the treatment with DMSO only when either a single treatment or continual treatment was employed.