Table 3.
Demographic and clinical characteristics associated with inclination for CHIP testing for self (n = 500)
| Characteristics | Inclined, n (%) | Disinclined, n (%) | Univariable OR for inclination (95% CI) | P value | Multivariable OR for inclination (95% CI) | P value |
|---|---|---|---|---|---|---|
| N | 400 (80) | 100 (20) | — | — | — | |
| Age at diagnosis, median (range), y | 37 (17-40) | 37 (26-40) | — | .959 | — | — |
| Age at survey, median (range), y | 46 (31-54) | 46 (33-52) | — | .774 | — | — |
| Mo from diagnosis, median (range) | 108 (60-168) | 108 (60-168) | — | .483 | — | — |
| Race | ||||||
| White∗ | 359 (90) | 85 (85) | — | — | — | — |
| Native American | 2 (<1) | 0 (0) | ∞ (0-∞) | .983 | — | — |
| Asian | 18 (5) | 9 (9) | 0.47 (0.21-1.14) | .079 | — | — |
| Black, Haitian, or African American | 10 (3) | 4 (4) | 0.59 (0.19-2.20) | .385 | — | — |
| Multiracial | 6 (1) | 1 (1) | 1.42 (0.24-27.02) | .747 | — | — |
| Other/unknown | 5 (1) | 1 (1) | 1.18 (0.19-22.84) | .878 | — | — |
| Ethnicity | ||||||
| Hispanic | 49 (12) | 18 (18) | 0.64 (0.36-1.17) | .134 | 0.62 (0.34-1.16) | .125 |
| Non-Hispanic∗ | 351 (88) | 82 (82) | — | — | — | — |
| Financial comfort at baseline | ||||||
| Comfortable∗ | 205 (51) | 65 (65) | — | — | — | — |
| Uncomfortable | 173 (43) | 33 (33) | 1.66 (1.05-2.67) | .032 | 1.61 (1.01-2.61) | .050 |
| Unknown | 22 (6) | 2 (<2) | 3.49 (0.99-22.14) | .097 | 0.47 (0.07-3.70) | .418 |
| Education at baseline | ||||||
| College and above∗ | 365 (91) | 95 (95) | — | — | — | — |
| Below college | 15 (4) | 5 (5) | 0.78 (0.29-2.45) | .640 | 0.69 (0.25-2.22) | .501 |
| Unknown | 20 (5) | 0 (0) | ∞ (0-∞) | .977 | ∞ (0-∞) | .984 |
| Breast cancer stage | ||||||
| 0 | 32 (8) | 15 (15) | 0.69 (0.34-1.41) | .290 | — | — |
| I∗ | 137 (34) | 44 (44) | — | — | — | |
| II | 184 (46) | 30 (30) | 1.97 (1.18-3.32) | .010 | — | — |
| III | 47 (12) | 11 (11) | 1.37 (0.67-2.99) | .401 | — | — |
| Chemotherapy | ||||||
| Yes | 308 (77) | 60 (60) | 2.33 (1.45-3.71) | <.001 | 2.18 (1.35-3.49) | .001 |
| No∗ | 86 (22) | 39 (39) | — | — | — | — |
| Unknown | 6 (2) | 1 (1) | 2.72 (0.44-52.31) | .362 | 0.49 (0.02-12.65) | .618 |
| Radiotherapy | ||||||
| Yes | 253 (63) | 59 (59) | 1.20 (0.77-1.88) | .416 | — | — |
| No∗ | 146 (37) | 41 (41) | — | — | — | — |
| Unknown | 1 (<1) | 0 (0) | ∞ (0-∞) | .982 | ||
| Genetic testing summary | ||||||
| Negative∗ | 274 (69) | 78 (78) | — | — | — | — |
| Positive | 59 (15) | 7 (7) | 2.40 (1.12-5.95) | .037 | — | — |
| VUS | 24 (6) | 4 (4) | 1.71 (0.64-5.94) | .335 | — | — |
| Information not available or not tested | 43 (11) | 11 (11) | 1.11 (0.57-2.36) | .767 | — | — |
CI, confidence interval; OR, odds ratio; VUS, variant of uncertain significance.
∗
Reference category.