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Inhibition of MEK pathway leads to p53 activation. (A) Effect of small-molecule inhibitors of MEK and GSK (MEKi and GSKi) on ESC cell cycle profile. 2i denotes MEKi plus GSKi. (B) Quantification of FACS analysis as in (A) (n = 3). The bar plot represents mean ± SD. ∗, P < 0.05; ∗∗, P < 0.01; ∗∗∗, P < 0.001; ∗∗∗∗, P < 0.0001 (unpaired t test).(C) Effects of MEKi, GSKi or 2i on p53 protein.
