Table 3.
Areas under the curve values and the cut-off, sensitivity, and specificity values for genes and proteins dendritic cells by qRT-PCR and Immunohistochemistry on paraffin-embedded specimens.
| Markers | AUC | Cut-off | Sensitivity | Specificity | P value |
|---|---|---|---|---|---|
| IDO (gene) | 0.64 | 1.10 | 0.567 | 1 | 0.01 |
| CD11c (gene) | 0.61 | 1.12 | 0.51 | 1 | 0.046 |
| CD103 (gene) | 0.74 | 1.10 | 0.667 | 1 | P < 0.001 |
| CD207 (gene) | 0.75 | 1.10 | 0.717 | 1 | P < 0.001 |
| CD11c (protein) | 0.59 | 3.2500 | 0.867 | 0.412 | 0. 4 |
| CD103 (protein) | 0.86 | 43.75 | 0.800 | 0.824 | P = 0.001 |
| CD207 (protein) | 0.66 | 1.750 | 0.667 | 0.706 | P = 0.12 |
AUC: Area under the receiver operating characteristic curve; Cut-off: Marker value at which sensitivity and specificity are optimal.
AUC can be interpreted as follow: 90–100 = excellent; 80–90 = good; 70–80 = fair; 60–70 = poor; 50–60 = fail (18).