Table 4.

Mortality rates per 100 000 person-years among patients with dAATD and a matched Danish general population comparison cohort and mortality rate ratios

Mortality	AATD Patients mortality rate/ 100 000 pyrs	Danish population mortality rate/100 000 pyrs	Mortality rate ratio (95% CI)
Overall	5444	1169	4.7 (4.1 to 5.3)
By sex
Females	5774	1091	5.3 (4.5 to 6.3)
Males	5159	1239	4.2 (3.5 to 4.9)
By age (years)
≤18*	273	8	33.8 (6.8 to 167.4)
19–34*	343	39	8.8 (1.1 to 68.4)
35–44	2628	134	19.7 (11.1 to 34.8)
45–54	3341	323	10.3 (7.2 to 14.8)
55–64	6210	806	7.7 (6.1 to 9.8)
≥65	11 775	2780	4.2 (3.6 to 5.0)
By time period
2000–2004	16 439	923	17.8 (11.0 to 28.8)
2005–2009	8140	1076	7.6 (5.8 to 9.9)
2010–2014	5971	1176	5.1 (4.2 to 6.2)
2015–2018	3833	1201	3.2 (2.6 to 3.9)

*Age categories condensed because no deaths occurred among patients with AATD aged 13–18 years and 25–34 years.

AATD, alpha-1 antitrypsin deficiency; pop, population; pyrs, person years.