Table 3.
Grade profile summary of “omega-3 fatty acid for uremic pruritus” quality assessment
| Certainty assessment |
Number of patients |
Effect |
Certainty | Importance | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Number of studies | Study design | Risk of bias | Inconsistency | Indirectness | Imprecision | Other considerations | O3FA | Control | Relative (95% CI) | Absolute (95% CI) | ||
| Pruritus scores | ||||||||||||
| 5 | Randomised trials | Serious | Serious | Not serious | Not serious | Publication bias strongly suspected | 83 | 81 | - | SMD 1.34 lower (2.7 lower-0.01 higher) | ⨁◯◯◯ (very low) | Important |
| Duo pruritus scores | ||||||||||||
| 3 | Randomised trials | Serious | Not serious | Not serious | Not serious | Publication bias strongly suspected | 31 | 29 | - | SMD 0.85 lower (1.39 lower-0.3 lower) | ⨁⨁◯◯ (low) | Important |
CI: Confidence interval, O3FA: Omega-3 fatty acid, SMD: Standardized mean difference