Table 2. Multivariate Analysis for PFS and OS.

Cox proportional hazards regression analysis reporting hazard ratios (HRs) and 95% confidence intervals (95% CIs) using acute kidney injury (AKI) as the time-dependent variable by adjusting for gender, double/triple-hit status by fluorescence in situ hybridization (FISH), and the International Prognostic Index (IPI) score. Statistical significance (p<0.05) is denoted by shaded orange rows.

	Progression Free Survival
Factor	Univariate Cox Regression Hazard Ratio (95% CI)	p-value	Multivariate Cox Regression Hazard Ratio (95% CI)	p-value
Presence of AKI	1.91 (1.21 – 3.01)	0.005	1.99 (1.16 – 3.40)	0.012
Male Gender	1.47 (0.97 – 2.23)	0.071	1.68 (1.03 – 2.71)	0.036
Double or Triple-hit by FISH	1.19 (0.71 – 1.99)	0.516	1.04 (0.62 – 1.75)	0.888
IPI Score	1.67 (1.36 – 2.06)	<0.001	1.77 (1.41 – 2.22)	<0.001
	Overall Survival
Factor	Univariate Cox Regression Hazard Ratio (95% CI)	p-value	Multivariate Cox Regression Hazard Ratio (95% CI)	p-value
Presence of AKI	3.08 (1.84 – 5.15)	<0.001	3.52 (1.96 – 6.35)	<0.001
Male Gender	1.97 (1.13 – 3.41)	0.016	2.83 (1.52 – 5.25)	0.001
Double or Triple-hit by FISH	1.35 (0.75 – 2.44)	0.312	1.05 (0.58 – 1.90)	0.879
IPI Score	1.98 (1.53 – 2.57)	<0.001	2.23 (1.67 – 2.96)	<0.001