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. 2022 Dec 22;17:6607–6619. doi: 10.2147/IJN.S384196

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© 2022 Meng et al.

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(A) The objective to construct Hela subcutaneous tumor and the treatment process. (B) Schematic illustrating treatment by extratumoral light irradiation (E-L) or intratumoral light irradiation (I-L). Light intensity:100 mW cm⁻², time: 20 min. (C) Representative tumor images of the different groups after treatment. (D) Growth kinetic curves of tumors in tumor-bearing mice after receiving PyTPA@PEG or TB@PEG -mediated extratumoral light irradiation (E-L) or intratumoral light irradiation (I-L). The data were reported as mean ± SD (n = 4) and analyzed by unpaired t-test. * p< 0.05. (E) Body weight changes in mice during treatment. (F) The histological changes of tumors were observed by H&E staining. (G) Cell apoptosis of tumors were detected by TUNEL staining.