Table 3.

Nonbiologic systemic drugs in pediatric psoriasis

Drug	Indication	Dosage	Remarks
Methotrexate	Moderate-severe plaque psoriasis Psoriatic arthropathy	Oral/subcutaneous 0.1-0.4 mg/kg/week and up to 1.25-5.0 mg/week Folic acid: 5 mg given daily to minimize size effects, except the day of methotrexate administration	Level of evidence: II-III Grade of recommendation : B
Cyclosporine	Severe unstable psoriasis Generalized pustular psoriasis Erythrodermic psoriasis	2-5 mg/kg/day	Level of evidence: II-III Grade of recommendation : B
Retinoids	Extensive guttate psoriasis Pustular psoriasis Erythrodermic psoriasis	0.3-0.5 mg/Kg/day for first 4 weeks, then increased to 0.5-1.0 mg/kg/day	Level of evidence: II -III Grade of recommendation : B