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Summary of epitope-mapping studies of neutralizing MAbs by SPR. We propose at least two distinct neutralizing epitopes from the MAb-mapping studies. One site is defined by MAb 6B2-2. Another site is defined by MAb 6E9-1 and is shared by all other MAbs tested except 6B2-2 and 6C2-4. The epitope of MAb 6C2-4 overlaps that defined by MAbs 4A2-2 and 4A2-4, which must therefore be overlapping rather than identical to the 6E9-1 binding site.
