Table 3.

Lambert-Eaton Myasthenic Syndrome – Clinical Symptoms and Signs

Symptoms	Signs on Examination
Proximal limb weakness (legs >arms)	Proximal weakness
Cranial weakness (mild)	Mild cranial weakness
Fluctuating symptoms	Objective weakness is less than predicted based on symptoms
Dry mouth	Absent/reduced muscle stretch reflexes
Other anticholinergic autonomic symptoms	Lambert Sign (2–3 seconds of maximal grip produces increase strength)
Metallic taste