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. 2022 Dec 12;13:1048980. doi: 10.3389/fphar.2022.1048980

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Copyright © 2022 Lin, Wang, Kang, Porpiglia, Chang, Huang, Bhimani, Abdul-Lattif, Azmat, Wang, Lin, Chang and Chi.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Forest plot and funnel plot of comparative overall survival and progression-free survival between PPI users and non-users in CRC cancer patients treated with fluorouracil-based regimens. The size of squares is proportional to the weight of each study. Horizontal lines indicate the 95% CI of each study; diamond, the pooled estimate with 95%. PPI, proton pump inhibitors; CI, confidential interval; CRC, colorectal cancers; FOLFOX, folinic acid, fluorouracil, and oxaliplatin; FOLFIRI, leucovorin, fluorouracil, and irinotecan; RAM, ramucirumab; IFL, irinotecan, leucovorin, and fluorouracil.