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. Author manuscript; available in PMC: 2022 Dec 26.
Published in final edited form as: J Genet Genomics. 2011 Sep 16;38(10):439–452. doi: 10.1016/j.jgg.2011.09.002

Fig. 2.

Fig. 2.

Context-specific functions of CDK8-CycC. Very little is known about the upstream regulators of CDK8-CycC. About 10 downstream effectors of CDK8 have been identified in multi-cellular organisms, and the transcriptional effect of their phosphorylation by CDK8 varies. It is likely that CDK8 has additional substrates that remain to be identified. Characterization of both upstream regulators and downstream effectors of CDK8-CycC is the key to understand how dysregulation of CDK8 contributes to tumorigenesis.