Table 2. Summary of lifespan and healthspan associations with GrimAges.
| Measure | Effect size | AgeAccelGrim2 | AgeAccelGrim | Location |
| Time-to-death | ||||
| All1 | Hazard ratio | 1.10 (P=3.6e-167) | 1.10 (P=2.0e-144) | Figure 2 |
| Smokers1 | Hazard ratio | 1.10 (P=4.2e-104) | 1.10 (P=3.0e-91) | Figure 3 |
| Non smokers1 | Hazard ratio | 1.09 (P=4.4e-43) | 1.10 (P=8.1e-34) | Figure 3 |
| Adjusted for blood cell composition2 | Hazard ratio | 1.09 (P=5.2e-123) | 1.09 (P=1.1e-104) | Supplementary Figure 16 |
| Time-to-CHD | Hazard ratio | 1.08 (P=4.5e-28) | 1.08 (P=2.7e-24) | Figure 4 |
| Comorbidity | -- | Stouffer’s P=3.0e-27 | Stouffer’s P=5.7e-22 | Figure 5 |
| Type 2 diabetes | Odds ratio | 1.07 (P=1.1e-30) | 1.05 (P=2.8e-15) | Supplementary Figure 8 |
| Disease free | -- | Stouffer’s P=7.2e-16 | Stouffer’s P=1.1e-10 | Supplementary Figure 10 |
| Mean carotenoids | bicor | -0.29 (P=8.4e-42) | -0.25 (P=4.5e-32) | Figure 6 |
| log2(C-reactive protein) | bicor | 0.32 (P=9.9e-276) | 0.26 (P=6.2e-178) | Figure 6 |
| FEV1 | bicor | -0.31 (P=1.1e-136) | -0.29 (P=2.1e-119) | Figure 6 |
| log2 (Waist/hip ratio) | bicor | 0.23 (P=3.9e-69) | 0.18 (P=3.6e-45) | Figure 6 |
| Current smoker | bicor | 0.35 (P=4.5e-299) | 0.36 (P=1.1e-363) | Figure 6 |
| Liver attenuation (Hounsfield unit) | bicor | -0.27 (P=1.18e-14) | -0.24 (P=2.79e-10) | Figure 7 |
| Visceral adipose tissue (CM3) | bicor | 0.22 (P=7.15e-12) | 0.20 (P=2.75e-12) | Figure 7 |
| HOMA-IR3 | bicor | 0.16 (5.27e-04) | 0.14 (9.74e-03) | Figure 8 |
| Granulocyte | Pearson correlation | 0.29 (P=1.2e-232) | 0.22 (P=1.1e-126) | Supplementary Figure 15 |
| CD4+T | Pearson correlation | 0.26 (P=3.7e-192) | -0.22 (P=6.1e-126) | Supplementary Figure 15 |
1refers to all and stratified by smoking group.
2refers to Cox regression models additionally adjusted for blood cell composition/count variables.
3GrimAge models were applied to saliva methylation data.
The table briefly summarizes our investigations for the associations of GrimAge2 and GrimAge with (1) mortality analysis across all validation datasets, stratification of smoking status, and specific Cox regression models adjusted for blood cell composition/counts and (2) a broad category of healthspan outcomes. The columns list names of mortality or healthspan related outcomes, type of effect size in association analysis, summary statistics in the format of effect size (meta P value) or Stuffer’s P value for AgeAccelGrim2 and AgeAccelGrim, and the location of corresponding figure. Abbreviation: bicor denotes a robust correlation coefficient (biweight midcorrelation [26]).