Table 2. The influencing factors of CD4+T cell count, Naïve CD4+ T cell and Memory CD4+T cell dynamics with mixed linear model.
| CD4+ T cell count | Naïve CD4+ T cell | Memory CD4+ T cell | ||||
| Unadjusted Est. Coef (SE)† | Adjusted Est. Coef (SE)† | Unadjusted Est. Coef (SE.)† | Adjusted Est. Coef (SE.)† | Unadjusted Est. Coef (SE)† | Adjusted Est. Coef (SE)† | |
| Age | ||||||
| 35–49 | −29 (17.4) | 11 (10.5) | −33 (8.1) | −15 (5.5) | 5 (10.5) | 20 (7.3)‡ |
| >50 | −35 (24) | −21 (14.7) | −55 (11.3) | −16 (7.6)‡ | 19 (14.6) | 51 (10.3) ‡ |
| 18–35 | 0 | |||||
| Gender | ||||||
| Female | −30 (24.2) | −17 (14.5) | −21 (11.5) | 4 (7.7) | −5 (14.5) | 1.4 (10.1) |
| Male | 0 | |||||
| CD4 count at baseline (cell/μl) | ||||||
| 50–100 | 44 (25.3) | 49 (19.4)‡ | NA | NA | NA | NA |
| 100–200 | 119 (20.2) | 128 (15.3‡ | NA | NA | NA | NA |
| >200 | 308 (16.4) | 329 (12.6)‡ | NA | NA | NA | NA |
| <50 | 0 | |||||
| Years after ART initiation (years) | ||||||
| 0.25 | 109 (4.6) | 108 (5.1)‡* | 37 (2.5) | 33 (3.3)‡* | 72 (3.5) | 72 (3.8)‡* |
| 0.5 | 133 (6.2) | 133 (7.1)‡* | 46 (3.3) | 40 (3.7)‡* | 87 (4.6) | 87 (5.3)‡* |
| 1 | 169 (7.3) | 167 (8.3)‡* | 59 (3.9) | 51 (4.0)‡* | 110 (5.3) | 110 (6.2)‡* |
| 2 | 225 (8.2) | 224 (9.1)‡* | 82 (4.3) | 73 (4.1)‡* | 145 (5.8) | 146 (6.8)‡* |
| 3 | 255 (9.1) | 253 (9.8)‡* | 93 (4.8) | 87 (4.5)‡ | 160 (6.4) | 162 (7.3)‡* |
| 4 | 275 (9.9) | 274 (10.5)‡ | 99 (5.3) | 87 (4.8)‡ | 174 (7.0) | 177 (7.7)‡ |
| 5 | 291 (11.1) | 292 (11.2)‡ | 100 (5.8) | 90 (5.0)‡ | 192 (7.7) | 197 (8.2)‡ |
| 6 | 312 (11.8) | 315 (11.9)‡ | 103 (6.3) | 95 (5.3)‡ | 208 (8.2) | 214 (8.7)‡ |
| 7 | 316 (12.9) | 322 (12.7)‡ | 105 (6.8) | 102 (5.8)‡ | 204 (8.9) | 213 (9.3)‡ |
| 8 | 334 (14.2) | 347 (13.7)‡* | 112 (7.5) | 102 (5.8)‡* | 220 (9.8) | 232 (10.0)‡ |
| 9 | 357 (16.1) | 377 (15.3)‡* | 118 (8.5) | 110 (6.5)‡* | 234 (11.0) | 249 (11.2)‡* |
| 10 | 350 (18.5) | 380 (17.4)‡* | 105 (9.8) | 109 (7.3)‡ | 239 (12.7) | 258 (12.7)‡* |
| 0 | ||||||
| ART regimen | ||||||
| 2NRTIs+PI | 84 (31.8) | 105 (19.2)‡ | 42 (15.2) | 37 (9.9)‡ | 42 (19.2) | 20 (13.4) |
| 2NRTIs+INSTI | 4 (26.8) | 68 (16.8)‡ | −1 (12.8) | 15 (8.1) | 3 (16.4) | 28 (11.7)‡ |
| Others | 55 (30.1) | 63 (18.0)‡ | 25.6 (14.36) | 13 (9.4) | 23 (18.1) | 7 (12.5) |
| 2NRTIs+NNRTI | 0 | |||||
| VL<50cps/ml | ||||||
| No | 84 (4.8) | 1 (5.6) | 32 (2.5) | 9 (3.0)‡ | 59 (3.6) | 0 (4.2) |
| Yes | 0 | |||||
| Baseline naïve+T cell increase per 50/ul | NA | NA | 68 (2.0) | 55 (2.7) | ||
Abbreviations: †Est. Coef.: estimated coefficient; SE.: standard error ‡Between group comparisons of the difference of values at particular time points and the baseline value, P-Value <0.05; *Adjusted multiple comparisons when compared with indicators at 5-year of ART, P-Value < 0.05.