Table 3.

Median plasma concentration of the top 26 classifying proteins, ICU Day-3

Protein	Healthy Controls	Sepsis Day-3	Change	P-Value	Corrected P-Value
TIMP1	17.58 (16.19–17.89)	40.17 (27.01–54.83)	↑	< 0.0001	0.0016
IL4RA	2.08 (1.90–2.22)	6.56 (3.63–8.15)	↑	< 0.0001	0.0016
PRTN3	6.04 (4.79–7.27)	21.62 (15.90–27.30)	↑	< 0.0001	0.0016
UPAR	6.56 (5.83–7.88)	13.75 (11.00–27.40)	↑	< 0.0001	0.0016
OPN	11.85 (9.44–15.29)	70.09 (43.82–78.26)	↑	< 0.0001	0.0016
CHI3L1	6.60 (5.82–8.32)	51.95 (27.92–68.54)	↑	< 0.0001	0.0016
ST2	5.00 (4.48–5.47)	44.50 (16.73–72.03)	↑	< 0.0001	0.0016
TNFRSF10A	5.33 (4.82–5.92)	10.20 (8.48–14.02)	↑	< 0.0001	0.0016
VSIG4	17.45 (14.62–19.43)	94.61 (47.58–203.81)	↑	< 0.0001	0.0016
ANGPT2	3.94 (3.37–4.07)	9.90 (7.78–16.06)	↑	< 0.0001	0.0016
NTproBNP	7.94 (5.64–12.64)	204.13 (66.21–817.22)	↑	< 0.0001	0.0016
GDF8	11.32 (9.56–16.78)	2.11 (1.61–2.88)	↓	< 0.0001	0.0016
PVR	218.29 (199.04–243.63)	309.93 (285.85–389.24)	↑	< 0.0001	0.0016
GCP5	14.86 (12.61–16.55)	6.36 (4.92–8.15)	↓	< 0.0001	0.0016
NTRK3	107.56 (103.68–118.03)	62.54 (49.32–70.67)	↓	< 0.0001	0.0016
ITGAV	26.03 (24.62–28.56)	15.99 (11.29–17.31)	↓	< 0.0001	0.0016
WFDC2	374.19 (323.03–402.35)	985.66 (767.97–1208.01)	↑	< 0.0001	0.0016
CXCL13	134.98 (116.85–164.03)	446.75 (279.79–716.64)	↑	< 0.0001	0.0016
GALNT7	16.62 (14.71–18.76)	9.52 (7.20–10.56)	↓	< 0.0001	0.0016
KIM1	110.58 (93.33–161.57)	590.88 (461.90–854.33)	↑	< 0.0001	0.0032
TNFR1	19.92 (17.61–23.92)	49.37 (33.71–86.61)	↑	< 0.0001	0.0032
SPINK1	7.53 (6.75–9.08)	75.56 (22.32–239.37)	↑	< 0.0001	0.0032
ASGR1	10.53 (9.60–11.96)	32.71 (20.44–42.41)	↑	< 0.0001	0.0032
CNTN5	24.25 (21.81–25.63)	8.72 (6.28–10.84)	↓	< 0.0001	0.0032
PLXDC1	7.34 (6.79–8.14)	4.71 (3.93–5.21)	↓	< 0.0001	0.2174
NPM1	11.89 (8.82–13.24)	30.37 (22.76–38.50)	↑	< 0.0001	0.7839