Fig. 4.

Personalised in-silico brain model to predict therapeutic outcomes. The principles of Dynamic Sensitivity Analysis using whole-brain computational models open up for novel clinical intervention design. The schematic provides a pipeline for how to combine functional information about the brain spatio-temporal dynamics in a model to describe the aberrant brain state (leftmost). Once the model is optimised, exhaustive Dynamic Sensitivity Analysis can be performed to establish perturbation sites, profiles and/or durations for optimally rebalancing the aberrant dynamics towards a target brain state. Lastly, based on the optimal perturbation profile, clinical interventions can be suggested that are most compatible with the suggested in-silico intervention.