Table 3.
Summary of studies investigating the cardio-metabolic effects of matcha tea.
| Reference | Subject | Year | Dose | Duration | Methods | Results |
|---|---|---|---|---|---|---|
| Zhou et al. (2021) | Male C57BL/6 mice | 2021 | HFD + 0.1%, 0.5% and 1% matcha vs control vs HFD | 6 weeks | Tissue weight |
 Weight gain rate |
| Body weight |
food intake (kcal/d) |
|||||
| Food intake | Improved BG and lipid profile | |||||
| TG, TC, LDL, Blood Glucose (BG) |
Alanine transaminase, Aspartate transaminase |
|||||
| Histologic analysis of epididymal adipose tissue |
 Upregulated cytochrome P450 |
|||||
| Liver tissue (lipid accumulation, ALT, AST, and inflammation: TNF-α, IL-6, IL-1β) |
Downregulated lipid droplet-associated proteins |
|||||
| Liver transcriptome analysis | ||||||
| PPI network analysis | ||||||
| Xu et al. (2016) | Male ICR mice | 2016 | Control vs HFD vs HFD+0.025% or 0.05% or 0.075% matcha vs HFD+0.05% matcha extract or residue. | 4 weeks | Body weight |
Weight gain (best 0.05%), TC, TG, LDL, BG. |
| Blood and liver samples |
HDL |
|||||
| Superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) |
Superoxide Dismutase, Glutathione Peroxidase, Malondialdehyde (serum and liver) |
|||||
| Lipid peroxidation | ||||||
| Zhou et al. (2020) | Male C57BL/6 mice + Mouse microglial BV-2 cells |
2020 | Control vs HFD (60%E from fat) vs HFD + 0.1%, 0.5% and 1% matcha | 6 weeks | Serum glucose |
Weight gain |
| TG, TC, LDL, HDL |
BG, TG, TC, LDL, fat accumulation in epididymal area |
|||||
| Adipose tissue samples |
Inflammatory cytokines |
|||||
| Hypothalamus samples | X No effect on food intake and HDL | |||||
|
Inhibited JAK2 and STAT3 phosphorylation |
Abbreviations: HFD, High-fat diet; IL-1β, Interleukin-1 beta; IL-6, Interleukin- 6; JAK2, Janus kinase 2; LDL, Low-density lipoprotein; PPI, Protein-protein interactions; STAT3, Signal transducer and activator of transcription 3; TC, Total cholesterol; TG, Triglycerides; TNF-α, Tumor-necrosis factor-alpha.