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. 2022 Dec 13;13:1090958. doi: 10.3389/fneur.2022.1090958

Table 4.

The performance of biomarkers in distinguish between normal children and cognitive impairment induced by cblC-MMA.

Parameters AUC (95%CI) P-value
HCY 0.926 (0.875–0.976) < 0.001
C3 0.713 (0.589–0.836) 0.001
C0 0.663 (0.535–0.791) 0.004
C3/C0 0.737 (0.617–0.856) < 0.001
Methylmalonic acid in urine 0.941 (0.897–0.986) < 0.001
Methylmalonic acid in serum 0.955 (0.921–0.990) < 0.001
Methylmalonic acid in serum total exosomes 0.961 (0.924–0.999) < 0.001
Methylmalonic acid in serum neuro-exosomes 0.921 (0.870–0.971) < 0.001

HCY, homocysteine; C3, propionylcarnitine; C0, free carnitine; neuro-exosomes neuronal-derived exosomes.

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