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. 2022 Dec 13;9:1067207. doi: 10.3389/fmolb.2022.1067207

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Copyright © 2022 Harada and Sakamoto.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Classification of treatment-survived cells by proliferation rate and chemotherapy time course. Each color corresponds to the cell classifications shown in the included table. We divided the cell populations into four main categories: parental, drug-tolerant persisters (DTPs), recurrence, and resistant. In DTPs, we showed slow-cycling and cycling subcategories, pre-exist and arise populations in detail. Recurrence populations include slow-cycling and cycling populations, which could arise due to cell plasticity and/or genomic alternations. The resistant population was categorized according to the timeline of treatment: multiple or long-term chemotherapies.